Detalhe da pesquisa
1.
A transchromosomic rat model with human chromosome 21 shows robust Down syndrome features.
Am J Hum Genet
; 109(2): 328-344, 2022 02 03.
Artigo
Inglês
| MEDLINE | ID: mdl-35077668
2.
Humanized UGT2 and CYP3A transchromosomic rats for improved prediction of human drug metabolism.
Proc Natl Acad Sci U S A
; 116(8): 3072-3081, 2019 02 19.
Artigo
Inglês
| MEDLINE | ID: mdl-30718425
3.
CYP3A4 Induction in the Liver and Intestine of Pregnane X Receptor/CYP3A-Humanized Mice: Approaches by Mass Spectrometry Imaging and Portal Blood Analysis.
Mol Pharmacol
; 96(5): 600-608, 2019 11.
Artigo
Inglês
| MEDLINE | ID: mdl-31455676
4.
Characterization of P-Glycoprotein Humanized Mice Generated by Chromosome Engineering Technology: Its Utility for Prediction of Drug Distribution to the Brain in Humans.
Drug Metab Dispos
; 46(11): 1756-1766, 2018 11.
Artigo
Inglês
| MEDLINE | ID: mdl-29777024
5.
Trans-chromosomic mice containing a human CYP3A cluster for prediction of xenobiotic metabolism in humans.
Hum Mol Genet
; 22(3): 578-92, 2013 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-23125282
6.
Retargeting of microcell fusion towards recipient cell-oriented transfer of human artificial chromosome.
BMC Biotechnol
; 15: 58, 2015 Jun 19.
Artigo
Inglês
| MEDLINE | ID: mdl-26088202
7.
A novel transchromosomic system: stable maintenance of an engineered Mb-sized human genomic fragment translocated to a mouse chromosome terminal region.
Transgenic Res
; 23(3): 441-53, 2014 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-24488595
8.
Knockout of mouse Cyp3a gene enhances synthesis of cholesterol and bile acid in the liver.
J Lipid Res
; 54(8): 2060-2068, 2013 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-23709690
9.
Highly stable maintenance of a mouse artificial chromosome in human cells and mice.
Biochem Biophys Res Commun
; 442(1-2): 44-50, 2013 Dec 06.
Artigo
Inglês
| MEDLINE | ID: mdl-24216103
10.
Full-length human dystrophin on human artificial chromosome compensates for mouse dystrophin deficiency in a Duchenne muscular dystrophy mouse model.
Sci Rep
; 13(1): 4360, 2023 03 16.
Artigo
Inglês
| MEDLINE | ID: mdl-36928364
11.
Analysis of in vitro and in vivo metabolism of zidovudine and gemfibrozil in trans-chromosomic mouse line expressing human UGT2 enzymes.
Pharmacol Res Perspect
; 10(6): e01030, 2022 12.
Artigo
Inglês
| MEDLINE | ID: mdl-36424908
12.
Complete genetic correction of ips cells from Duchenne muscular dystrophy.
Mol Ther
; 18(2): 386-93, 2010 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-19997091
13.
Quantitative prediction of P-glycoprotein-mediated drug-drug interactions and intestinal absorption using humanized mice.
Br J Pharmacol
; 178(21): 4335-4351, 2021 11.
Artigo
Inglês
| MEDLINE | ID: mdl-34232502
14.
Construction of stable mouse artificial chromosome from native mouse chromosome 10 for generation of transchromosomic mice.
Sci Rep
; 11(1): 20050, 2021 10 08.
Artigo
Inglês
| MEDLINE | ID: mdl-34625612
15.
A non-mosaic transchromosomic mouse model of down syndrome carrying the long arm of human chromosome 21.
Elife
; 92020 06 29.
Artigo
Inglês
| MEDLINE | ID: mdl-32597754
16.
Evaluation of 4ß-Hydroxycholesterol and 25-Hydroxycholesterol as Endogenous Biomarkers of CYP3A4: Study with CYP3A-Humanized Mice.
AAPS J
; 20(3): 61, 2018 04 09.
Artigo
Inglês
| MEDLINE | ID: mdl-29858698
17.
Modification of single-nucleotide polymorphism in a fully humanized CYP3A mouse by genome editing technology.
Sci Rep
; 7(1): 15189, 2017 11 09.
Artigo
Inglês
| MEDLINE | ID: mdl-29123154
18.
Cyp3a deficiency enhances androgen receptor activity and cholesterol synthesis in the mouse prostate.
J Steroid Biochem Mol Biol
; 163: 121-8, 2016 10.
Artigo
Inglês
| MEDLINE | ID: mdl-27137100
19.
Thalidomide-induced limb abnormalities in a humanized CYP3A mouse model.
Sci Rep
; 6: 21419, 2016 Feb 23.
Artigo
Inglês
| MEDLINE | ID: mdl-26903378
20.
A novel and stable mouse artificial chromosome vector.
ACS Synth Biol
; 3(12): 903-14, 2014 Dec 19.
Artigo
Inglês
| MEDLINE | ID: mdl-23654256